6th Year Bioengineering Ph.D. student. Lead developer of Olivar.
Michael (6th year PhD candidate, Bioengineering) obtained a B.E. degree in Biomedical Engineering from Tsinghua University in 2019. During his undergraduate, he did research in developing multiplexed droplet digital PCR (ddPCR) assays with Dr. Yong Guo. Before joining the Treangen Lab in 2022, he worked on design and optimization of multiplexed NGS assays with Dr. David Y. Zhang (Xie et al., 2022; Wu et al., 2022; Zhang et al., 2021). His primary research interest is algorithms for multiplexed primer and probe design, under the setting of wastewater pathogen surveillance (Wang et al., 2024; Wu et al., 2024; Wolken et al., 2024). Michael likes playing all kinds of sports and loves music.
Michael is supported by CDC award (75D30122C14709) and NSF CAREER (IIS 2239114).
References
2024
Olivar: towards automated variant aware primer design for multiplex tiled amplicon sequencing of pathogens
Michael X Wang, Esther G Lou, Nicolae Sapoval, and 8 more authors
@article{wang2024olivar,title={Olivar: towards automated variant aware primer design for multiplex tiled amplicon sequencing of pathogens},author={Wang, Michael X and Lou, Esther G and Sapoval, Nicolae and Kim, Eddie and Kalvapalle, Prashant and Kille, Bryce and Elworth, RA Leo and Liu, Yunxi and Fu, Yilei and Stadler, Lauren B and others},year={2024},journal={Nature Communications},publisher={Nature Publishing Group UK London},volume={15},number={1},pages={6306}}
Multiplexed detection, partitioning, and persistence of wild type and vaccine strains of measles, mumps, and rubella viruses in wastewater
Jingjing Wu, Michael X Wang, Prashant Kalvapalle, and 6 more authors
@article{wu2024multiplexed,title={Multiplexed detection, partitioning, and persistence of wild type and vaccine strains of measles, mumps, and rubella viruses in wastewater},author={Wu, Jingjing and Wang, Michael X and Kalvapalle, Prashant and Nute, Michael and Treangen, Todd J and Ensor, Katherine and Hopkins, Loren and Poretsky, Rachel and Stadler, Lauren B},year={2024},journal={medRxiv},publisher={Cold Spring Harbor Laboratory Press},pages={2024--05}}
PreK-12 school and citywide wastewater monitoring of the enteric viruses astrovirus, rotavirus, and sapovirus
Madeline Wolken, Michael Wang, Julia Schedler, and 5 more authors
Science of The Total Environment, 2024
2022
Designing highly multiplex PCR primer sets with simulated annealing design using dimer likelihood estimation (SADDLE)
Nina G Xie, Michael X Wang, Ping Song, and 6 more authors
@article{xie2022designing,title={Designing highly multiplex PCR primer sets with simulated annealing design using dimer likelihood estimation (SADDLE)},author={Xie, Nina G and Wang, Michael X and Song, Ping and Mao, Shiqi and Wang, Yifan and Yang, Yuxia and Luo, Junfeng and Ren, Shengxiang and Yu, Zhang David},journal={Nature communications},volume={13},number={1},pages={1881},year={2022},publisher={Nature Publishing Group UK London}}
Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling
Lucia Ruojia Wu, Peng Dai, Michael Xiangjiang Wang, and 8 more authors
@article{wu2022ensemble,title={Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling},author={Wu, Lucia Ruojia and Dai, Peng and Wang, Michael Xiangjiang and Chen, Sherry Xi and Cohen, Evan N and Jayachandran, Gitanjali and Zhang, Jinn Xuemeng and Serrano, Angela V and Xie, Nina Guanyi and Ueno, Naoto T and others},journal={Nature communications},volume={13},number={1},pages={1791},year={2022},publisher={Nature Publishing Group UK London}}
2021
A deep learning model for predicting next-generation sequencing depth from DNA sequence
Jinny X Zhang, Boyan Yordanov, Alexander Gaunt, and 8 more authors
@article{zhang2021deep,title={A deep learning model for predicting next-generation sequencing depth from DNA sequence},author={Zhang, Jinny X and Yordanov, Boyan and Gaunt, Alexander and Wang, Michael X and Dai, Peng and Chen, Yuan-Jyue and Zhang, Kerou and Fang, John Z and Dalchau, Neil and Li, Jiaming and others},journal={Nature communications},volume={12},number={1},pages={4387},year={2021},publisher={Nature Publishing Group UK London}}
